08/27/2026
The PKU screen, or newborn heel prick test ✨️
What is it for & what are the risks?
The PKU screen is a standard newborn test that checks for dozens of medical conditions. Some conditions include phenylketonuria (PKU), galactosemia, maple syrup urine disease, congenital hypothyroidism, Sickle cell disease, homocystinuria, congenital adrenal hyperplasia, and more. These conditions, if undiagnosed in a timely manner, can lead to poor outcomes.
The test is collected by a nurse or phlebotomist, who will first warm the baby's heel, prick it using an infant lance, and then apply the drops of blood to fill 5 circles on a piece of paper. The newborn is typically 24hours old when this test is completed. This paper will then be dried in the lab before being mailed to one of the labs in the country that is capable of completing the PKU screen.
The test is very low risk. Some may not be comfortable completing this test if they have concerns about what happens to their baby's blood & DNA after the test is completed. You may have concerns about the pain the heel prick poses for your baby. To reduce pain, ensure that the heel is first warmed before the prick is carried out, so that blood flows easily and quickly. If you are nursing, latch your baby while they are pricked. Studies have shown a measureable reduction in pain when infants are breastfed through painful procedures.
In Nebraska, there is no opt-out option if you are planning to get a birth certificate. The certificate will not be issued until the screen has been completed.
What are the PKU regulations in your state? Did nursing during the test help your baby through it? Did the newborn screen catch anything that you are grateful for?